SnAP reagents for the synthesis of piperazines and morpholines.

Intramolecular Pd(II)-catalyzed aerobic oxidative amination of alkenes: synthesis of six-membered N-heterocycles.

Use of a base-free Pd(DMSO)(2)(TFA)(2) catalyst system enables the synthesis of six-membered nitrogen heterocycles via a Wacker-type aerobic oxidative cyclization of alkenes bearing tethered sulfonamides. Various heterocycles, including morpholines, piperidines, piperazines, and piperazinones, are accessible by this method.

Synthesis and Properties of Selected 4-Substituted Anhydro Sugars

A new class of 4-deoxy-4-([4-substituted-l-piperazinyl], [4-morpholinyl] and [4-(perhydrol,4-thiazin-4-yl)])-2,3-anhydrolyxopyranosides (3a-g and 6a-g) were synthesized from ep­ oxy triflate moities 2 and 5 and 4-substituted piperazines, morpholines and perhydro-1,4thiazines, respectively, to test their antibacterial activity. The characterized series of new compounds was tested in vitro agains...

De Novo Assembly of Highly Substituted Morpholines and Piperazines

The morpholine and piperazine with their remarkable physical and biochemical properties are popular heterocycles in organic and medicinal chemistry used in rational property design. However, in the majority of cases these rings are added to an existing molecule in a building block approach thus limiting their substitution pattern and diversity. Here we introduce a versatile de novo synthesis of...

Reaction Between Grignard Reagents and Heterocyclic N-oxides Synthesis of Substituted Pyridines, Piperidines and Piperazines

New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines

Functionalized morpholines have attracted much attention due to their potential biological activities. Despite the wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their synthesis remains relatively unexplored. Given the low cost and easy availability of N-propargylamines, the synthesis of functionalized morphol...